Science

Our ScienceIntroducing CLM296: A Next-Generation Therapy

CLM296 is Theranib’s groundbreaking first-in-class ALDH1A3 inhibitor, designed to address critical challenges in cancer treatment. With its unique mechanism of action and unparalleled specificity, CLM296 represents a transformative step forward in oncology.

Key Features of CLM296

Therapeutic FocusAddressing Critical Needs in Oncology

Breast Cancer
Targeting aggressive forms of breast cancer with high ALDH1A3 expression to reduce metastasis and improve survival outcomes.
Lung Cancer
Addressing chemotherapy-resistant non-small cell lung cancers by inhibiting ALDH1A3-driven tumor progression.
Colorectal Cancer
Offering precision therapies to patients with advanced colorectal cancer, focusing on reducing recurrence rates.
Prostate Cancer
Tackling metastatic prostate cancer through ALDH1A3 inhibition to enhance treatment efficacy and reduce drug resistance.
Glioblastoma
Developing innovative treatments for this aggressive brain cancer, with a focus on limiting tumor growth and improving quality of life.
Pancreatic Cancer
Aiming to provide new therapeutic options for one of the most challenging cancers to treat due to its resistance to conventional therapies.
Combination Therapy
Enhancing the effectiveness of standard-of-care treatments by integrating ALDH1A3 inhibitors for synergistic outcomes.
Benefits of VE3Revolutionizing Cancer Treatment with Targeted Solutions
  • Improved Survival Rates: Tackling chemotherapy resistance and metastasis directly enhances survival outcomes for patients with aggressive cancers.

  • Personalized Treatment: Biomarker-driven diagnostics ensure CLM296 is administered to patients who will benefit most, maximizing its effectiveness and minimizing unnecessary treatments.

  • Wide Applicability: CLM296 has shown potential across multiple cancer types, including breast, lung, colorectal, prostate, and glioblastoma, addressing high unmet needs in oncology.

  • Combination Therapy Advantage: CLM296 amplifies the efficacy of existing therapies, making it an ideal candidate for integration into current treatment regimens.

  • Safer and More Tolerable: Preclinical studies indicate a favorable safety profile with minimal toxicity, improving patient quality of life during treatment.

  • Transformational Potential: As the first-in-class ALDH1A3 inhibitor, CLM296 represents a new approach to cancer care, providing hope for patients where standard treatments have failed.

Key Challenges We SolveAdvancing Cancer Care
Therapy Resistance
Reduces the efficacy of cancer treatments by limiting their capacity to eliminate resilient tumor cells, hindering recovery.
Tumor Progression
Accounts for over 90% of global cancer deaths, driven by the aggressive spread of secondary tumors to distant organs.

Pipeline TimelineA Strategic Roadmap for Precision Medicine

< 2023

Compound Development and Early Research

2023

Initial Patent Filing

2023

Phase 1: Early Preclinical Work

2023

Funding Secured

2024

US Patent Filing

2024

Phase 2: In Vivo Efficacy Studies

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